glp-1 ra vs glp-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease Beneficial Effects of Glucagon-Like Peptide-1

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Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)

N Engl J Med 398:205216

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